Depends on which icons you're looking to replace, but yeah, you should be able to.
Madonote This will replace your basic ones, like the file folders, My Comp, etc. It also does a ton of other stuff, but I only ever use it for the icons.
IconTweaker This is icons only, but it will also replace file icons and other icon types.
what gid said, i personally use iconpackager mainly because it was the most readily available at the time
...I've just totally been convinced that the first thing I should do when I get home is to mod my icons ; D; Tates yours look great! And mmm, Tekkon Kinkreet goodness 
Gids asked me to post this :]
Using three different sets of icons for those generic ones + skypod icon lifted off tat0es... while I'm at it Gids, the brown that I get when hovering over like the right click menu or menus in general is different from the modified brown in the task bar xD Still cool though, thanks for doing the color fix - looks tons better with different desktops. x3
Oh. That's in the text file, I didn't think to look and see if there was anything going on there.
Got bored today so redressed my desktop. Its basically all centered around akka's Sandwich VS with modifications of other skins here and there to match.
Firefox: homepage made to match
Foobar: Elegance by jclim00 (with custom backdrop)
GRJ: AMANA by doneld
Icons: Sandwich by fate0000
Launchy:Sandwich by akka
Miranda: away by Maximhuz (modified by me to match Sandwich)
Samurize: own config
Visual Style: Sandwich by akka
Wall: Sandwich_purple by akka
Nice dude, I like the consistency of everything.
yea if possible, i think its always best to utilize material from just one suite if possible. i just wish Sandwich had a more diverse range of icons.
Quoting crap:
..you know for icons that are essentially permanent on your desktop, you might as well put them in a dock. Takes hardly anymore resources and looks alot better at least imo. The major benefit being, you can use pngs rather then ico files.

I finally caved and installed RocketDock. And it is awesomely sweet. Not to say I've completely gotten rid of my sea of icons, but it's definitely an improvement because the number of icons I had just kept creeping up and up. I guess that's one of the downsides of having a huge screen... almost too much icon space haha, whereas before I'd force myself to clean up after 3 or 4 rows because that would be icons pollution for about half my screen xD
you could try the stack docklet, it could help with icon clutter i imagine. it basically works as a folder but that opens in the dock as either a stack or grid.
and 3/4 rows of icons is insane btw. i at most have 4 single icons on my desktop at once...and thats usually simply stuff im downloading.
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As you can see, the setup stays the same for the most part.


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